Can I make wudu with a prosthetic limb?

Yes, you can make wudu with a prosthetic limb. The prosthetic is not part of your body, so you don't wash it. You wash whatever remains of the limb within the wudu area, and if nothing of that area remains, that part of wudu simply drops. Islam never asks you for more than you can do.
What you wash and what drops
Wudu means washing the face, the arms up to and including the elbows, wiping the head, and washing the feet up to and including the ankles. Scholars of all four schools agree on how this works after an amputation:
- Arm amputated below the elbow: wash what is left of the forearm and the elbow itself.
- Arm amputated above the elbow: the duty to wash that arm falls away. Many scholars recommend washing the end of the stump anyway, but it isn't required.
- Leg amputated below the ankle: wash what remains of the foot and the ankle.
- Leg amputated above the ankle: washing that foot drops.
Make sure water reaches all the skin that remains in the wudu area. The Prophet ﷺ once saw a man who had left a dry patch the size of a fingernail on his foot and told him to go back and do his wudu well (Sahih Muslim 243).
Do I take the prosthetic off?
If the prosthetic covers skin you need to wash, like a below-elbow arm or a below-ankle foot, take it off, wash the skin, and put it back on. Most scholars don't allow wiping over a prosthetic the way you wipe over leather socks, because it can be removed.
If removing it is genuinely hard, painful or harmful, many contemporary scholars treat it like a cast: you wipe over it, or use tayammum for that part. See Can I make wudu with a cast or bandage? and How do I do tayammum?
Does putting it on or off break wudu?
No. Taking off or putting on a prosthetic is not one of the things that break wudu. Only the usual things do, like using the toilet, passing wind or deep sleep. See What breaks wudu? So you can make wudu at home, put the limb back on and go out for the day.
Prosthetics are allowed in Islam
There's nothing wrong with wearing a prosthetic. A Companion called Arfajah lost his nose in battle, and the Prophet ﷺ allowed him to replace it with one made of gold (Sunan Abi Dawud 4232). Replacing a lost body part to live a normal life is a mercy, not a problem.
If standing, bowing or prostrating is hard, you can also pray sitting on a chair or on the floor in whatever way you're able.
- You don't wash the prosthetic itself.
- Wash whatever remains of the limb inside the wudu area.
- If nothing of that area remains, that step drops.
- If removing it causes real hardship, wipe over it or use tayammum.
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