Is alcohol-based hand sanitizer najis?

No, according to many contemporary scholars. The alcohol in hand sanitizer is a disinfectant, not an intoxicating drink, so they do not treat it as najis. You can use it and then pray without washing it off. Those who follow the stricter view simply wash their hands with water first.
Why many scholars allow it
The classical discussion about alcohol being najis was about wine and other intoxicating drinks. The alcohol in sanitizer, medicine and cleaning products is a different substance: it is made for disinfecting, it is poisonous to drink, and nobody uses it as a beverage. Many contemporary scholars therefore say it is not najis, so it does not stop you praying.
Hardship is also considered. Hand sanitizer is part of normal life in hospitals, schools and workplaces, and Islam avoids unnecessary difficulty:
The Quran forbids drinking intoxicants (Quran 5:90), and that is the heart of the ruling. Using sanitizer on your skin has nothing to do with drinking. The wider debate is covered separately. See Is alcohol najis?
The stricter view
Some scholars follow the classical view that alcohol is najis and extend it to any alcohol used on the body. If you follow that view, there is an easy solution: wash your hands with water and soap before praying, or use an alcohol-free sanitizer. This is a personal choice; you are not sinning if you follow the majority of contemporary scholars.
Does sanitizer affect my wudu?
- Does it break wudu? No. If you are already in wudu, you can sanitize your hands and still pray.
- Can it replace wudu? No. Wudu is done with water, and sanitizer is not water.
- Should I let it dry first? If you can, yes, so that your hands are not sticky or wet with gel. But it is not required.
- What if I sanitize before wudu? You do not need to wash it off separately. The water in your wudu will remove it anyway.
Wudu has to be done with water, not gel. See Can I use hand sanitizer instead of wudu?
Practical tips
- Soap and water is better for hygiene when you can use it, and it fits every view.
- Keep alcohol-free sanitizer in your bag if you prefer the stricter view.
- Do not swallow sanitizer or use it near the mouth. It is dangerous to drink.
- If your hands are very dry, a small amount of moisturiser after it is fine.
For perfumes, deodorants and body sprays that contain alcohol, the same discussion applies. See Is perfume with alcohol haram?
- Many contemporary scholars say sanitizer alcohol is not najis, so you can use it and pray.
- The classical ruling was about intoxicating drinks (Quran 5:90).
- The stricter view is to wash your hands with water before prayer.
- Sanitizer neither breaks wudu nor replaces it.
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